BMS-1166 can disrupt PD-1/PD-L1 interaction with IC50 value of 1.4nM. It can antagonize the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.

PD-1/PD-L1 inhibitor 1 is a small-molecule inhibitor of PD-1/PD-L1 interaction with IC50 of 6 nM.

PD1-PDL1 inhibitor 2 is an inhibitor of the PD-1 (Programmed death- 1) /PD-Ll (Programmed death-ligand 1) protein/protein interaction with IC50 of 18 nM.

PD-1/PD-L1 Inhibitor 3 is capable of inhibiting the interaction of PD-L1 with PD-1 and with CD80.