NMS-859 is a potent and specific small molecule covalent inhibitor of the ATPase VCP/p97 (IC50 ~0.37 μM), identified by high-throughput screening.

ML241 HCl is a potent and selective inhibitors of p97 ATPase with IC50 values of 100 nM.

MNS is a tyrosine kinase inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively. It acts by inhibiting NLRP3 ATPase activity and binding to the NACHT and LRR domains.

DBeQ is a selective, potent, reversible, and ATP-competitive p97 inhibitor with IC50 of 1.5 μM.

MSC1094308 is a reversible, allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B.

CB-5083 is a potent, ATP-competitive, D2-selective, and orally bioavailable p97 inhibitor with IC50 of 11nM.

NMS-873 is a potent, selective allosteric VCP/p97 inhibitor with IC50 value of 20 nM (Wild Type, 1 mM ATP).

Eeyarestatin I is a potent inhibitor of endoplasmic reticulum associated protein degradation (ERAD).