Tenovin-3 is able to increase p53 levels, determined in MCF-7 cells treated for 6 hr at 10 μM.

10-Shogaol, a natural product isolated and purified from the rhizomes of Zingber officinale Rosc., an antioxidant for human skin cell growth and a migration enhancer with potential to be a wound repair agent, has similar metabolic profiles to [6]-shogaol and exhibit similar toxicity toward human colon cancer cells.

CP-31398 2HCl is a p53 stabilizing agent which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.

APR-246, is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types.

Pifithrin-α hydrobromide is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes.

NSC319726 is a mutant p53R175 reactivator inhibiting growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM) and showing no inhibition for p53 wild-type cells.

COTI-2 is an orally available thiosemicarbazone and mutant p53 activator with potential antineoplastic activity.

Tenovin-1 is an inhibitor of SIRT1 and SIRT2 and an activator of p21 and p53. It protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2.

PK11007 is a p53 targeting compond anti-tumor activities.

PRIMA-1 is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.

(+)-Pinocembrin could inhibit p53 expression causing a lower Bax/Bcl-2 ratio and the release of cytochrome c that shows a neuroprotective effects. (+)-Pinocembrin can be extracted from the fruit of alpinia katsunadia hayata with antioxidant and anti-inflammatory antivities.

Kevetrin HCl is an activator of the tumor suppressor protein p53 with potential antineoplastic activity.

Serdemetan acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, and inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53.

RG7112 is a small-molecule MDM2 antagonist which can occupy the p53-binding pocket of MDM2.

NSC-207895 (XI-006), a DNA damaging agent, is an anticancer agent and p53 activator.

RITA induced both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks. It is MDM2-p53 interaction inhibitor and activates p53 expression.

AMG-232 is a highly potent, selective and orally bioavailable piperidinone inhibitor of the MDM2-p53 interaction ((SPR KD= 0.045 nM, SJSA-1 EdU IC50=9.1 nM).

CBL0137 HCl is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 of 0.47 µM.

Pifithrin-μ is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.