Acumapimod is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 μM for p38α.

TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.

SD-06 is a p38 MAP kinase inhibitor and inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats(83% inhibition at 1mg/kg, po).

AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity.

SKF-86002 is a potent inhibitor of p38 MAP kinase with IC50 of 0.5-1 μM and inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM).

Sertaconazole nitrate is a topical broad-spectrum antifungal that is developed to provide an additional agent for the treatment of superficial cutaneous and mucosal infections.

Dehydrocorydaline chloride is an alkaloidal that has anti-inflammatory and anti-cancer activities.

UM-164 is a potent dual c-Src/p38 kinase inhibitor that exhibits potent anti-TNBC activity in xenograft models. UM-164 inhibits p38 kinase and binds to an inactive c-Src conformation.

ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 (SR-B1).

Isobavachromene is a natural product isolated and purified from the seeds of Psoralea corylifolia L..