Tpl2 Kinase Inhibitor 1 (Compound 1) is a potent and selective Tpl2 (COT kinase, MAP3K8) inhibitor that plays an important role in the regulation of the inflammatory response and the progression of some cancers[1].

3,4-Dihydroxyhydrocinnamic acid is a metabolite product of the hydrogenation of caffeoylquinic acids, occurring in normal human biofluids, with potent antioxidant properties.

Doramapimod is a highly selective p38α MAPK inhibitor with Kd of 0.1 nM, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2, ZAP-70, EGFR, HER2, PKA, PKC, PKCα/β/γ.

Rutundic acid, a natural product isolated and purified from the leaves of Ilex pubescens Hook. et Arn. with antitumor activity, exhibits potent tumor cell growth inhibiting property against Hela, A375, HepG2 , NCI-H446, and SPC-A1.

VX-702 is a highly selective inhibitor of p38α MAPK with IC50 of 4 -20 nM.

Losmapimod is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively.

BMS-582949 HCl is a highly selective p38α MAPK inhibitor, inhibits p38α with IC50 of 13 nM.

PD169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor (IC50 = 89 nM).

Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.

VX-745 is a potent and selective inhibitor of p38α with IC50 of 10 nM, 22-fold greater selectivity versus p38β and no inhibition to p38γ.

Dilmapimod is a selective p38 MAPK inhibitor. It is used in neuropathic pain and acute respiratory distress syndrome.

Chonglou saponin VII, a natural product isolated and purified from the roots of Paris polyphylla, shows inhibitory effects on cell proliferation.

Deoxynivalenol is a tricothecene mycotoxin and potent protein synthesis inhibitor.