SB-408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, and exhibits 50-fold selectivity over OX2 receptor.

MK-3697 is an isonicotinamide small molecule, acting as a potent and selective Orexin 2 receptor antagonist with Ki = 0.95 nM.

SB-334867 free base is a selective non-peptide orexin OX1 receptor antagonist with pKb of 7.2.

Almorexant HCl is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.

TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively).

YNT 185 is potent and selective orexin OX2 receptor agonist with EC50 of 28 nM at human OX2 expressed in CHO cells. YNT 185 displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells).

MK-1064 is a selective orexin 2 receptor antagonist(2-SORA) for the research of insomnia.

Seltorexant is a selective orexin-2 receptor antagonist that has been shown to promote sleep in various species.

PF-3274167 is a high-affinity nonpeptide oxytocin receptor (OTR) antagonist, with Ki of 9.5 nM.

Oxytocin acetate is a mammalian neurohypophysial hormone and its actions are mediated by specific, high-affinity oxytocin receptors and ligand of oxytocin receptor.

for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models[1][2].

EMPA is highly potent, selective OX2 receptor antagonist with IC50 values of 2.3 nM and 1900 nM for OX2 and OX1 respectively.

SB-649868 is a potent and selective orally active orexin (OX) 1 and OX2 receptor antagonist (pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).

Almorexant is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.