Oxysophocarpine, a natural product isolated and purified from the root of Styphnolobium japonicum (L.) Schott., can decrease the level of serum transaminase, improve lipid metabolism, reduce synthesis of inflammatory cytokines TNF-α, TGF-β1 and IL-6, activate protective adipocytokine adiponectin, and may be a drug for colonic inflammation and NASH.

(+)-Corynoline is an AChE inhibitor isolated from Corydalis incisa.

(R)-Sulforaphane, a natural product isolated and purified from brocoli, is a promising potential chemopreventitive agent in bladder cancer.

RA-839 is a noncovalent small molecule binder to Keap1 and selective activator of Nrf2 signaling. RA-839 also suppresses LPS-induced iNOS and nitric oxide expression in macrophages.

Eriodictyol, a flavonoid isolated and purified from the fruits of Citrus sinensis (L.) Osbeck with anti-inflammatory and antioxidant activities, may possess antidiabetic properties through increasing glucose uptake and improving insulin resistance and be a potential therapeutic resource for Atopic dermatitis and an adjunctive agent to control itchiness in Atopic dermatitis.

AKBA is a novel Nrf2 activator which can increase basal and UVA-induced levels of Nrf2.

4-Hydroxy-3-methoxycinnamaldehyde is an isoflavonoid isolated and purified from Senra incana with anti-apoptosis activity.

Brusatol is a plant-derived natural quassinoid that exhibits broad cytotoxicity in cancer cultures (IC50 < 1 μM against 457 cancer cell lines) by inhibiting de novo synthesis of cellular proteins (Effective conc. < 50 nM in A549 cells), including NRF2.

Eriodictyol-7-O-glucoside, a natural product isolated and purified from the herbs of Dracocephalum rupestre, can activate Nrf2/ARE signaling, directly associated with its neuroprotection against oxidative stress-induced ischemic, suggesting that targeting the Nrf2/ARE pathway may be a promising approach for therapeutic intervention in stroke.