SB-222200 is a selective, reversible and competitive antagonist of human NK-3 receptor (Ki=4.4 nM) that effectively crosses the blood-brain barrier.

Tradipitant is the 2nd generation neurokinin-1 receptor antagonist, which showed activity in preclinical anxiety models.

Fezolinetant is Neurokinin-3 (NK-3) receptor antagonist.

Substance P TFA (Neurokinin P TFA) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R)[1].

L-732138 is a potent and highly selective competitive tachykinin NK1 receptor antagonist with IC50 of 2.3 nM.

Aprepitant is a selective and high-affinity neurokinin-1 receptor antagonist with IC50 of 0.1 nM.

Netupitant a potent and highly selective NK1 receptor antagonist with Ki of 0.95 nM.

Maropitant is a neurokinin (NK1) receptor antagonist.

Fosaprepitant Dimeglumine is a prodrug for aprepitant which is a selective and high-affinity antagonist of NK1 receptor.

Rolapitant inhibits CYP2D6, breast cancer resistance protein (BCRP), and Neurokinin (NK)1 Receptor.