L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.

DEN is an extremely potent liver carcinogen.

L-Arginine HCl is a substrate of NOS and a nonessential amino acid in human.

Molsidomine is a long-acting vasodilating drug used to treat angina pectoris.