NF-κB-IN-1 is a potent NF-κB signaling pathway inhibitor. It inhibits NF-κB by inhibiting IκB phosphorylation and degradation via IKK blockage.

Magnolol is a multifunctional compound isolated from the Chinese medicinal plant Magnolia officinalis, with antifungal, antibacterial and antioxidant effects, as well as anti-inflammatory activity by interferring with NF-κB signaling and inhibiting IL-6-induced STAT3 activation.

CID-2858522 selectively inhibits the NF-κB pathway (IC50 < 0.1 μM for PMA-stimulated IL-8 production) induced by PKC, operating downstream of PKC but upstream of IKKbeta, without inhibiting other NF-kappaB activation pathways.

IT-603 is a c-Rel inhibitor with IC50 value of 3μM.

Polydatin, extracted from the roots ofPolygonum cuspidatumSieb, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models.

Erdosteine is a thiol derivative used as a mucolytic.

Stachydrine HCl is a naturally occuring anti-metastatic agent in vitro which is isolated from seed husk and the pulp of the fruit of C. Leonurus.

4'-Hydroxychalcone has diverse biological activities including inhibiting TNFα-induced NF-κB pathway activation and activating BMP signaling. It is found in herbs and spices and tea, is a member of the class of compounds known as retrochalcones.

Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the NF-κB signal pathway.

Nimbolide is a terpenoid lactone isolated and purified from A. indica (Neem tree) that demonstrates antimalarial and anticancer effects in experimental models.