TAS4464 selectively inhibits NAE relative to the other E1s UAE and SAE.

MLN4924 is a potent and selective small molecule NEDD8-activating enzyme (NAE) inhibitor (IC50 = 4.7 nM).

NAcM-OPT is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor, which specific and reversible inhibits the interaction of N-Acetyl-UBE2M and DCN1 with IC50 of 79 nM in TR-FRET assays.

Deoxyvasicinone, a natural product isolated and purified from the herbs of Galium aparine L., can be considered as promising lead molecules for the development of more potent inhibitors of NEDD8-activating enzyme.

MLN4924 HCl is a potent and selective small molecule NEDD8-activating enzyme (NAE) inhibitor (IC50 = 4.7 nM).