GLX351322 is an inhibitor of NADPH oxidase 4, inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μ M.

APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively.

GKT137831 is a specific dual Nox1/Nox4 inhibitor with Ki of 140±40 nM and 110±30 nM and a potent inhibitor of fibrosis and hepatocyte apoptosis.

ML171 is a novel and selective NOX1 inhibitor with IC50 value of 0.25 μM for blocking NOX1-dependent ROS generation in a HEK293-NOX1 recombinant cell system.

GSK2795039 is a small molecule NADPH Oxidase 2 Inhibitor.

8-Epideoxyloganic acid, a natural product isolated and purified from the herb of Lamiophlomis rotata, with anti-inflammatory activity, weak antinociceptive activity and bioactivities of analgesia, homeostasis, has the potential to serve as anti-inflammatory agents during oxidative stress, the inhibition of ROS production, possibly through modulation of NOX activity and/or the radical scavenging effect, and beta2 integrin expression in leucocytes.

Fluorofenidone attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and ECM deposition via the PI3K/Akt signalling pathway, suggesting AKF-PD is a potential novel therapeutic agent against renal fibrosis.

Apocynin is potent and selective NADPH-oxidase inhibitor with IC50 value of 10 μM.

Rehmannic acid, a natural product isolated and purified from the herbs of Lantana camara, inhibit succinoxidase activity, and is a potent uncoupler, abolishing the phosphate uptake, the respiration being inhibited by the former and increased by the latter.