Bufalin a major digoxin-like immunoreactive component of the Chinese medicine Chan Su and has been shown to exert a potential for anticancer activity against various human cancer cell lines in vitro.

Oleandrin, a natural product isolated and purified from the herbs of Nerium oleander L., inhibits the activity of NF-κB in various cultured cell lines (U937, CaOV3, human epithelial cells and T cells) as well as it induces programmed cell death in PC3 cell line culture.

Bisacodyl is a Na+/K+-ATPase inhibitor used as a stimulant laxative drug.

Sanguinarine chloride is a naturally occuring benzophenanthridine alkaloid which can inhibit sodium/potassium-ATPase protein (Na+/K+ ATPase) and cause Epidemic dropsy.

Oleic acid is a fatty acid that occurs naturally in various animal and vegetable fats and oils. It is also used as an activator of Na+/K+ ATPase.

Acevaltrate is a natural product a natural product isolated and purified from Valeriana kilimandascharica.

Istaroxime is a potent inhibitor of Na+,K+-ATPase with IC50 of 0.11 μM.

Chloroprocaine HCl is a local anesthetic during surgical procedures.

Annonacin, a natural product isolated and purified from the herbs of Annona glabra, is mitochondrial complex I inhibitor, reported to be more toxic than rotenone to mesencephalic neurons, and can cause significant cell death in various cancer cell lines.