MMP-9-IN-1 is a specific matrix metalloproteinase-9 (MMP-9) inhibitor that selectively targets the hemopexin (PEX) domain of MMP-9.

JNJ0966 is a selective inhibitor of MMP-9 zymogen (IC50 = 440nM) that inhibits subsequent generation of the catalytically active enzyme. It showed no effect on the catalytic activity of MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14, and did not inhibit the activation of MMP-2 zymogen.

CL-82198 is a selective inhibitor of MMP-13.

ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM).

GI 254023X is a potent and selective ADAM10 metalloproteinase inhibitor.

Prinomastat is a spectrum inhibitor of MMP with IC50s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and MMP-9 respectively.

Broad spectrum MMP inhibitor

S 3304 is a novel MMP inhibitor.

L-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms including NOS1, NOS2, and NOS3. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 µM, respectively.

TAPI-2 is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20±10 μM for MMP.

Disintegrin and Metalloproteinase Domain-Containing Protein 17 (ADAM17; TACE) Inhibitors, MMP-1 (Interstitial Collagenase) Inhibitors, MMP-13 (Collagenase 3) Inhibitors, MMP-2 (Gelatinase A) Inhibitors, MMP-7 (Matrilysin) Inhibitors, MMP-9 (Gelatinase B) Inhibitors, Signal Transduction Modulators

Abametapir is the active ingredient of Xeglyze Lotion. Abametapir inhibits metalloproteinases; enzymes that are essential to physiological processes critical for egg development and the survival of nymph and adult lice. In vitro and ex vivo research has demonstrated that abametapir not only kills the lice, but also prevents hatching of their eggs. Xeglyze Lotion is emerging as a differentiated development candidate to treat head lice infestations.