PF-06260933 is a selective inhibitor of MAP4K4 with IC50s of 3.7 nM.

GNE-495 is a potent and selective MAP4K4 inhibitor with IC50 of 3.7 nM.

DMX-5084 is a MAP4K4 inhibitor.

MAP4K4-IN-3 (Compound 17) is a potent and selective MAP4K4 inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay. Antidiabetic agent[1].

GNE-220 is a potent and selective inhibitor of MAP4K4 with an IC50 of 7 nM, also inhibits MINK (MAP4K6), DMPK and KHS1 (MAP4K5) with IC50 of 9 nM, 476 nM and 1,110 nM.