Fingolimod is a sphingosine 1-phosphate (S1P) antagonist with IC50 of 0.033 nM in K562 and NK cells.

TC-G 1006 is a potent and orally active S1P1 agonist with EC50 of 18 nM, showing no activity on S1P3.

JTE 013 is a potent, selective S1P2 receptor antagonist with IC50 value of 17.6 nM.

Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM, respectively, shows weaker inhibition for LPA2, no activity at LPA4, LPA5, LPA6.