JW 642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively.

JJKK 048 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor with IC50 of 0.4 nM.

URB-602 is a selective and non-competitive MAGL with IC50 value of 28 µM (rat brain enzyme).

ABX-1431 works as both a cannabinoid receptor agonist and a MAGL inhibitor.

Ibrolipim is a Lipoprotein lipase activator.

RHC 80267 is a diacylglycerol (DAG) lipase inhibitor and an important second messenger in signal transduction pathways.

JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively.

KML29 is a highly selective and potent MAGL inhibitor with IC50s for 15, 43, and 5.9 nM in mouse, rat, and human brain proteomes, respectively.

Pristimerin is a natural product isolated and purified from the herb of Tripterygium wilfordii Hook.f.

DB2313 is a first-in-class potent small-molecule inhibitor of PU.1. DB2313 disrupts the interaction of PU.1 with target gene promoters and leads to down-regulation of canonical PU.1 transcriptional targets.

LCL521 2HCl, an inhibitor of acid ceramidase, shows anticancer actions of lysosomally targeted.

XEN445 is a potent and selective endothelial lipase inhibitor with IC50 of 0.237 μM.

JZL195 functions as a dual inhibitor of FAAH and MAGL with IC50 of 13 nM and 19 nM respectively in brain of mouse.

Orlistat is an approved reversible general lipase inhibitor with IC50 of 122 ng/mL, used to treat obesity.

Cetilistat is a novel pancreatic lipase used to treat obesity.