Trigonelline HCl is an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.

Trigonelline, a natural product isolated and purified from the seeds of Trigonella foenum-graecum L. with phytoestrogenic and antitumor effects, inhibits the adipogenesis by its influences on the expression PPARγ, which leads to subsequent down regulation of PPAR-γ mediated pathway during adipogenesis.

Cucurbitacin B belongs to a class of highly oxidized tetracyclic triterpenoids and could repress cancer cell progression.