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STF-083010 is a potent IRE1α endonuclease inhibitor which can block endogenous XBP1 mRNA splicing.
MKC3946 is a small-molecule IRE1α endoribonuclease domain inhibitor which can block XBP1 splicing.
APY29 is an allosteric modulator of IRE1α and inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α RNase activity.
In INS-1 cells, KIRA6 inhibits IRE1α auto-phosphorylation by Tg and XBP1 mRNA splicing by Tm in a dose-dependent manner.
MKC8866 is an inositol requiring enzyme 1 (IRE-1α) inhibitor with IC50<0.1 μM.
Tags: IRE1 | 细胞周期 | Cell Cycle | 内质网应激 | Endoplasmic reticulum stress | IRE1 相关产品
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