Carbaryl is an acetylcholinesterase inhibitor with IC50 of 13.6 nM for A. gambiae AChE2 expressed in Sf9 cells and Ki of 5.7 µM for rat brain AChE, it's a carbamate insecticide.

Heptadecan-1-ol is long chain alcohol which exhibits activity against Aphids.

Diazinon is a thiophosphoric acid ester, is a nonsystemic organophosphate insecticide, used to control cockroaches, silverfish, ants, and fleas.

Mitotane is a steroidogenesis inhibitor and cytostatic antineoplastic medication which is used in the treatment of adrenocortical carcinoma and Cushing's syndrome.

Pyrimethamine inhibits multidrug and toxin extrusion (MATE) transporter potently, it also inhibits dihydrofolate reductase (DHFR), used for protozoal infections and interferes with tetrahydrofolic acid synthesis from folic acid. Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways.

Nitenpyram is a nAchR agonist, used an antiparasitic drug.

Dinotefuran is the third generation of neonicotinoid group,which works through inhibiting nAchRs.

Umbelliferone, a natural product isolated and purified from the herbs of Ruta graveolens L., exhibits significant anticancer effects via the induction of apoptosis, cell cycle arrest and DNA fragmentation in HepG2 cancer cells.

Rotenone is a proven complex I inhibitor with IC50 value of 1.7 - 2.2 μM.

Emamectin benzoate acts as an activator of chloride channel via binding gamma aminobutyric acid (GABA) receptor and glutamate-gated chloride channels. It can disrupt nerve signals in arthropods.

Furilazole is a pesticide agent.

Scopine HCl salt is a naturally occuring α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock and also s a potential brain-targeting moiety for enhancing the brain uptake efficiency of chlorambucil.

DEET is the most common active ingredient in insect repellents.

Dimetridazole is a nitroimidazole class drug that combats protozoan infections.