AG1024 inhibits IGF-1R autophosphorylation with IC50 of 7 μM, less potent to IR with IC50 of 57 μM.

PQ401, a selective insulin-like growth factor-1 receptor blocker, is a diarylurea compound that inhibits IGF1R autophosphorylation with IC50 < 1 μM.

Picropodophyllotoxin is an orally active insulin-like growth factor-1 receptor (IGF-1R) inhibitor with IC50 of 1 nM, and exhibits little effect towards IR, FGFR, PDGFR and EGFR, and exerts no effects on microtubules and DNA topoisomerase II.

Ginsenoside Rg5 is a natural product isolated and purified from the roots of Panax ginseng C. A. Mey. showing anti-inflammatory effect.

BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM.

Linsitinib is highly potent, orally efficacious and highly selective, dual ATP-competitive inhibitor of IGF-1R (IC50= 35 nM) and insulin receptor (IC50=75 nM).

NVP-AEW541 is a potent inhibitor of IGF-1R with IC50 of 86 nM, 27-fold greater selectivity for IGF-1R than InsR.

XL228 is a protein kinase inhibitor targeting IGF1R, the Aurora kinases, FGFR1-3, ABL and SRC family kinases.

BMS-754807 is a potent and reversible inhibitor of IGF-1R/InsR with IC50 of 1.8 nM/1.7 nM, less potent to Met, Aurora A/B, TrkA/B and Ron, and shows little activity to Flt3, Lck, MK2, PKA, PKC etc.

Insulin, Human is a two-chain polypeptide hormone produced by the β-cells of pancreatic islets, it regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat.

Insulin, Bovine is a two-chain polypeptide hormone produced by the β-cells of pancreatic islets, it regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat.

Ceritinib is potent inhibitor against ALK with IC50 of 0.2 nM, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively.

AZD3463 is an orally bioavailable ALK inhibitor with Ki of 0.75 nM, which also inhibits IGF1R with equivalent potency.