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GSK2330672 is a highly potent, nonabsorbable ASBT (apical sodium-dependent bile acid transporter) inhibitor (hASBT IC50=42 ± 3 nM) which lowers glucose in an animal model of type 2 diabetes and shows excellent developability properties for evaluating the potential therapeutic utility of a nonabsorbable ASBT inhibitor for treatment of patients with type 2 diabetes.
Elobixibat is a potent ileal bile acid transporter (IBAT) inhibitor with IC50 values of 0.53 ± 0.17 nM, 0.13 ± 0.03 nM, and 5.8 ± 1.6 nM for human IBAT, mouse IBAT, and canine IBAT.
S-8921 is an ileal Na+/bile acid cotransporter (IBAT) inhibitor.
Tags: IBAT | 膜转运蛋白 | Membrane Transporter/Ion Channel | IBAT 相关产品
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