Xanthohumol D, a natural product isolated and purified from the herbs of Humulus lupulus, is a potent inhibitor of quinone reductase-2 (QR-2) with IC50 of 110μM.

8-Prenylnaringenin is a phytoestrogen isolated and purified from the herbs of Humulus lupulus with the highest estrogenic activity, shows slight activity in this assay but significant activity by immunostaining, improves mitochondrial function, whereas a high dose of XN (5 µM) worsens the functionality of this organelle, and has more potent effects on promoting osteoblastic bone formation and inhibiting osteoclastic bone resorption by ERα instead of ERβ than the two classic phytoestrogens: genistein and daidzein.

5-O-Methylnaringenin is a natural product isolated and purified from the herbs of Humulus lupulus.

Xanthohumol, a natural product isolated and purified from the herbs of Humulus lupulus and a potent chemotherapeutic candidate for cervical cancer, inhibits the development of obese patients as well as the progression of non-alcoholic fatty liver disease, and displays anti-hepatitis C virus activity in a cell culture system and may be potentially used as an alternative or complementary treatment against the hepatitis C virus.

3'-Methylflavokawin is a natural product isolated and purified from the herbs of Humulus lupulus showing cytotoxicity against HeLa cells, the IC 50 value comparable to xanthohumol (8.2-19.2 mM).