Eupalinolide A is one of the major bioactive germacrane sesquiterpenes in E. Lindleyanum, which is found to induce the expression of heat shock proteins (HSPs), particularly HSP70 via the activation of heat shock factor 1, and suppress stressor-induced apoptosis and melanin production.

Ganetespib is a unique triazolone-containing Hsp90 inhibitor with an IC50 of 4 nM in OSA 8 cells.

Icapamespib is a heat shock protein 90 (HSP90) inhibitor.

KW-2478 is a nonansamycin HSP90 inhibitor with IC50 of 3.8 nM.

TAS-116 is a potent and selective HSP90α/β inhibitor with Kis of 34.7 nM, 21.3 nM, respectively.

YUM70 is a GRP78 inhibitor with IC50 value of 1.5μM and resulted in ER stress-mediated apoptosis. It inhibited pancreatic cancer cell growth in vitro and showed in vivo efficacy in a pancreatic cancer xenograft model with no toxicity to normal tissues.

L-Glutamic acid γ-(p-nitroanilide) is a substrate for γ-glutamyl transpeptidase.

MKT-077 (FJ-776) is a water-soluble rhodacyanine dye with antitumor activity. It can bind to Hsp70 family member mortalin-2 and inhibit its interactions with p53.

BIIB021 is an orally available, fully synthetic small-molecule inhibitor of HSP90 with Ki and EC50 of 1.7 nM and 38 nM, respectively.

Apoptozole is an inhibitor of heat shock protein 70 (HSP70) and Hsc70. It induces caspase-dependent apoptosis.

Debio 0932 is a heat shock protein 90 (HSP90) inhibitor with strong affinity for HSP90 alpha/beta, high oral bioavailability and potent anti-proliferative activity against a broad range of cancer cell lines (with a mean IC50 of 220 nmol/L).

Dihydroberberine, a natural product isolated and purified from the tubers of Corydalis decumbens (Thunb.) Pers., has anti-tumor activity. Dihydroberberine improves in vivo efficacy in terms of counteracting increased adiposity, tissue triglyceride accumulation, and insulin resistance in high-fat-fed rodents, thus is potential therapeutic reagents for type 2 diabetes treatment.

PU-H71 is a potent Hsp90 inhibitor with IC50 of 50 nM.

Fmoc-Val-Thr(psi(Me,Me)pro)-OH is used for solid phase synthesis of peptides.