Dihydroberberine, a natural product isolated and purified from the tubers of Corydalis decumbens (Thunb.) Pers., has anti-tumor activity. Dihydroberberine improves in vivo efficacy in terms of counteracting increased adiposity, tissue triglyceride accumulation, and insulin resistance in high-fat-fed rodents, thus is potential therapeutic reagents for type 2 diabetes treatment.

KRIBB11 is an inhibitor of heat shock factor (HSF) inhibitor, with IC50 of 1.2 μM.

TRC051384 is a inducer of Hsp70.

NVP-BEP800 is a fully synthetic HSP90β inhibitor with IC50 of 58 nM, exhibits> 70-fold selectivity against Hsp90 family members Grp94 and Trap-1.

PF-04929113 is a potent and selective HSP90 inhibitor with Kd of 41 nM and induces Her-2 degradation with IC50 of 37 nM.

ML346 is an activator of Hsp70 with EC50 of 4600 nM in HeLa cell toxicity assay.

Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor with an IC50 value of 2 nM, and over 1000-fold selectivity to Grp94 against Hsp90α[1].

SNX-2112 is a potent synthetic heat shock protein 90 (HSP90) inhibitor with an IC50 of 0.92 μM for K562 cells.

KNK437 is a pan-HSP inhibitor, which inhibits the synthesis of inducible HSPs, including HSP105, HSP72, and HSP40.

JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor which shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages.

Alvespimycin HCl is a potent, water-soluble HSP90 inhibitor with IC50 of 62 nM.

XL888 is a specific and ATP-competitive Hsp90 inhibitor with IC50 of 24 nM.

AT13387 is a selective potent Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity.

NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of < 10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.

Elesclomol, an inhibitor of HSP90, is a potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells.

CCT 018159 is a novel inhibitor of heat shock protein 90 (Hsp90) ATPase activity with IC50 of 5.7 μM.