Saikosaponin B2, a natural product isolated and purified from the herb of Bupleurum chinense DC., acts on HCV E2, inhibits infection by several genotypic strains and prevents binding of serum-derived HCV onto hepatoma cells, and induces differentiation of B16 melanoma cells at a concentration of 5 mM, with potentiation of expressions of melanogenesis and tyrosinase.

4-Phenoxybenzylamine can stabilize the NS3 protein in an inactive state with IC50 of 500 μM.

PSI-6130 is a potent and selective inhibitor of HCV NS5B polymerase.

Peretinoin, an acyclic retinoid, can alter lipid metabolism and inhibit HCV RNA amplification and virus release.

Voxilaprevir is used for the treatment of Hepatitis C virus infection.

VCH-916 is a nonnucleoside HCV NS5B polymerase inhibitor.