2'-Fluoro-5-methylarabinosyluracil is the impurity of antiviral drug clevudine , which is used for the treatment of Hepatitis B.

Morphothiadin, also known GLS4, is a potent and selective inhibitor of hepatitis B virus. GLS4 demonstrated potent inhibitory activities in HBV HepG2.2.15 cell assay with an EC50 value of 1nM, and it also exhibited high potency against various drug-resistant HBV viral strains with EC50 values in the range of 10-20nM, more potent than the typical HBV polymerase inhibitors such as lamivudine, telbivudine, and entecavir. Pharmacokinetic profiles of GLS4 were favorable and safety evaluation including acute toxicity and repeated toxicity study indicated that GLS4 was safe enough to support clinical experiments in human.

Inarigivir (ORI-9020;SB-9000) is a dinucleotide which can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus.

3’,5’-Di-O-benzyl Entecavir is an intermediate in the preparation of the hepatitis B antiviral agent entecavir.

Entecavir is a guanosine analogue that inhibits reverse transcription, DNA replication and transcription in the viral replication process, and is a potent, orally-active and selective inhibitor of HBV with an EC50 of 3.75 nM in HepG2 cell.

NVR3-778 is a first-in-class capsid assembly modulators currently in phase II clinical trial for the treatment of HBV infection. It exhibited anti-HBV activity with IC50 value of 0.26 µM.

Isoscopoletin is a natural product isolated and purified from the herbs of Paederia scandens (Lour.) Merr.

AB-423 is Arbutus' first-generation capsid inhibitor, which was generally safe and well tolerated in Phase 1 healthy volunteer studies.

Oxymatrine is a quinolizidine alkaloid extracted from the root of Sophora flavescens, which is used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases.

BAY-41-4109 racemate can inhibit human hepatitis B virus (HBV) with IC50 of 53 nM.