CHIR-99021 is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM, exhibiting > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases.

SB-216763 is potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 9 nM) and competes with ATP.

CHIR-98014 (CT98014) is highly selective aminopyrimidine-derivatived inhibitor of GSK-3 with IC50 of 650nM and 580nM for GSK-3 and GSK-3(measured by kinase assays), respectively, and exhibits >1000-fold selectivity for GSK-3 over closely related kinases, such as cdc2.

TWS119 is inhibitor of glycogen synthase kinase-3β with IC50 of 30 nM.

Tideglusib is an irreversible GSK-3 inhibitor with IC50 of 5 nM and 60 nM for GSK-3βWT (1 h preincubation) and GSK-3βC199A (1 h preincubation), respectively.

SB-415286 is an ATP-competitive inhibitor of GSK3α/GSK3β with IC50 of 78 nM and Ki of 31 nM.

AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor of GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respectively, shows > 14-fold selectivity against CDK2, CDK5, CDK1 and Erk2.

AR-A014418 is a selective inhibitor of GSK3β with IC50 of 104 ± 27 nM.

TDZD-8, the derivative of thiadiazolidinone, is a selective inhibitor of GSK-3. It inhibits GSK-3β with IC50 of 2 μM.

LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50s of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β respectively.

IM-12 is a GSK-3β inhibitor with IC50 of 53 nM.

1-Azakenpaullone is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, > 100-fold selectivity over CDK1/cyclin B and CDK5/p25.

Indirubin is a purple 3,2- bisindole and a stable isomer of indigo isolated from Indigo naturalis (Apiaceae) with anti-inflammatory and anticancer activities.

BIO-acetoxime is an inhibitor of GSK3α and GSK3β with IC50 of 10 nM.