Napellonine is a natural product isolated and purified from the roots of Aconitumso ngoricum Popov showing favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays.

Jujuboside A, a natural product isolated and purified from the seeds of Zizyphus jujuba with neurophysiological inhibitory effects, performs its specific sedative and hypnotic effect through not only adjusting GABA receptors subunit mRNAs expression, but also down-regulating the secretion of relevant inflammation cytokines on the intestinal mucosal system to affect the intercellular cytokine network between nerve cells in the brain and may serve as a potential therapeutic agent for the treatment of Alzheimer׳s disease.

Baclofen, a gamma-amino-butyric acid derivative, is a selective GABAB agonist with IC50 of 200 nM which used as a skeletal muscle relaxant.

CGP52432 is an antagonist of GABAB receptor with an IC50 of 85 nM.

MRK-016 is a functionally selective, inverse agonist at the benzodiazepine site of GABAA α5 receptors.

Pipequaline is a partial agonist of benzodiazepine receptor (Ki = 78 nM) with anxiolytic activity.

Gabazine hydrobromide is a drug that acts as an antagonist at GABAA receptors. It is used in scientific research and has no role in medicine, as it would be expected to produce convulsions if used in humans.