AP1867 is a synthetic FKBP12^F36V-directed ligand, used as a warhead in a series of heterobifunctional degraders (PROTACs) targeting FKBP12^F36V.

PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an VHL binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrader[1].

dTAG-13 is a thalidomide-based PROTAC targeting mutant FKBP12^F36V fusion proteins.