Coumestrol, a natural product isolated and purified from the herbs of Erythrina arborescens, exhibits activities against cancers, neurological disorders, and autoimmune diseases. It suppresses proliferation of ES2 cells with an IC50 of 50 μM.

XCT-790 is an agonist of estrogen related receptor alpha (ERRα) and can induce death of cancer cells resistant to chemotherapy.

Endoxifen E-isomer HCl is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM).

Eprotirome is a liver-selective thyroid hormone receptor agonist.

Nafoxidine HCl is a non-steroidal selective estrogen receptor modulator (SERM) or partial antiestrogen of the triphenylethylene group that was developed for the treatment of advanced breast cancer.

(R)-Equol is an agonist of both ERα and ERβ with Kis of 27.4 and 15.4 nM, respectively.

Lasofoxifene is a non-steroidal selective estrogen receptor modulator (SERM).

G15 is a high-affinity and selective GPER receptor antagonist with Ki value of 20nM.

4-Hydroxytamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer.

Dihydroresveratrol, a potent phytoestrogen, is a hormone receptor modulator. Dihydroresveratrol exhibits proliferative effects in androgen-independent prostate and breast cancer cells at picomolar and nanomolar concentrations.

Lynestrenol is a progesterone receptor agonist. It is synthetic progestational hormone.