SCH772984 is a specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively.

LY3214996 can inhibit ERK1 and ERK2 with IC50s of 5 nM.

VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK (Extracellular Signal-Regulated Kinase) and is antitumor agent.

Ulixertinib is a potent and reversible ERK1/ERK2 inhibitor with IC50 of < 0.3 nM for ERK2.

GDC-0994 is highly selective for ERK1 and ERK2, with IC50 of 1.1 nM and 0.3 nM, respectively.

FR 180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2 with Ki value of 0.31 μM and 0.14 μM respectively and has IC50 values of 0.51 and 0.33 μM in enzymatic assays against ERK1 and ERK2, respectively.