for hPI3k. SKI V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P). SKI V induces apoptosis and has antitumor activity[1][2].

ASTX-029 is selective inhibitor of the extracellular signal-regulated kinases 1 and 2 (ERK 1/2) with potential antineoplastic activity.

KO-947 is a potent and selective inhibitor of ERK1/2 kinases with potential clinical utility in MAPK pathway dysregulated tumors.

Ulixertinib HCl, the salt of ulixertinib, is a reversible inhibitor of ERK1/ERK2. It can inhibit cell proliferation.

ERK5-IN-1 exhibits potent inhibition of ERK5 with cellular EC50 values of 0.19 μM and enzymatic IC50 values of 0.087 μM and of LRRK2[G2019S] with enzymatic IC50 values of 0.026μM.

TIC10 is a brain-permeable and pharmacokinetics-improved Akt inhibitor, also inactivates ERK.

6-OAU is a surrogate agonist of GPR84 activating human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay.

PD184161 is an orally-active MEK inhibitor with antitumor effects in HCC in vitro and in vivo that appear to correlate with suppression of MEK activity.

Magnolin, a natural product isolated and purified from the flowers of Magnolia biondii Pamp., reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro.

ERK5-IN-2 is a selective ERK5 inhibitor with IC50 value of 0.82 μM.

XMD8-92 is an inhibitor of ERK5/BMK1. The Kd values for BMK1, DCAMKL2, PLK4 and TNK1 are 80 nM, 190 nM, 600 nM and 890 nM respectively.

Loureirin B is one of the active components in Sanguis draxonis.