AG 825 is a selective inhibitor of ErbB2 and the IC50 values are 0.15 and 19 μM for ErbB2 and ErbB1 respectively.

AG-490 is a broad-spectrum inhibitor that has several targets including EGFR (IC50 = 2 μM), ErbB2 (IC50 = 13.5 μM), STAT3 and JAK2.

Dacomitinib is a potent, orally available, irreversible tyrosine kinase HER 1 (EGFR), HER2 and HER4 inhibitor with IC50 of 6, 45.7 and 73.7 nM for EGFR, ERBB2 and ERBB4, respectively.

Poziotinib is an irreversible Pan-HER inhibitor with IC50s of 3/5/23 nM for HER1/HER2/HER4 respectively.

JNJ 28871063 hydrochloride is a selective ErbB receptor family inhibitor with IC50 values of 21, 22 and 38 nM for ErbB4, EGFR and ErbB2 respectively.