Hinokiflavone, a natural product isolated and purified from the leaves of Platycladus orientalis, with significant cytotoxicity, can inhibit the activity of MMP-9.

N106 is an activator of SUMO-activating enzyme E1 ligase. It can increase SERCA2a SUMOylation and activity and enhance contractility in rat cardiomyocytes in vitro.

Ginkgolic acid is a natural product isolated and purified from the leaves of Ginkgo biloba L.with suspected cytotoxic, allergenic, mutagenic and carcinogenic properties.

Smurf1-IN-A01 is an inhibitor of negatively regulatory factor Smurf1 for promoting bone formation.

SZL P1-41 is Skp2 inhibitor, selectively suppresses Skp2 E3 ligase activity, but not activity of other SCF complexes.

SJ-172550 is a small molecule inhibitor of MDMX and competes for the wild type p53 peptide binding to MDMX with an EC50 of 5 μM.

VL285 is a potent VHL ligand, degrading HaloTag7 fusion proteins.

Skp2 inhibitor C1 is a specific small molecule inhibitor of Skp2-mediated p27 degradation, selectively inhibited Skp2-mediated p27 degradation by reducing p27 binding through key compound-receptor contacts.

E3 ligase Ligand 9 is a Bestatin-based E3 ligase ligand.

ML-792 is a mechanism-based SUMO-activating enzyme (SAE) inhibitor with nanomolar potency in cellular assays, which selectively blocks SAE enzyme activity and total SUMOylation, thus decreasing cancer cell proliferation.

PRT4165, an inhibitor of bim1 and ring1A, could block PRC1 (Polycomb-repressive complex 1)-mediated H2A ubiquitylation.

VH-298 is a highly affinity inhibitor of E3 ubiquitin ligase VHL inhibitor (Kd = 80-90 nM) which can block the interaction of VHL and HIF-α, thus initiating hypoxic response.