EHT 5372 is a strong inhibitor of DYRK’s family kinases, with IC50s of 0.22, 0.28 nM for DYRK1A and DYRK1B, respectively.

INDY is inhibitor of DYRK1B and DYRK1A with IC50 values of 0.23 and 0.24 μM respectively.

GSK 626616 is a potent and selective DYRK inhibitor with IC50 of 0.7 nM for DYRK3, similar potency for DYRK1 and 2.

Neobavaisoflavone, an isoflavone isolated from the seeds of Psoralea corylifolia, has striking anti-inflammatory and anti-cancer effects.

AZ Dyrk1B 33 is a potent and selective ATP-competitive Dyrk1B kinase inhibitor with IC50 of 7 nM.

AZ 191 is a potent and selective DYRK1B inhibitor with IC50 of 17 nM in a cell-free assay, about 5- and 110-fold selectivity over DYRK1A and DYRK2, respectively.

ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, showing > 10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B.

GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6 nM and 16 nM, respectively

Clk inhibitor T3 is a highly selective, stable CLK inhibitor with high specificity to CLK1-3 protein isoforms.