Chlorprothixene is an antagonist of multiple receptors including 5-HT2 (Ki = 3.4 nM), D1 (Ki = 18 nM), D2 (Ki = 18 nM), D3 (Ki = 4.56 nM), H1 (Ki = 3.75 nM), muscarinic acetylcholine receptors, α1-Adrenergic.

Lurasidone functions as an antagonist of the dopamine D2 and D3 receptors, the serotonin 5-HT2A and 5-HT7 receptors, the α2C-adrenergic receptor, and as a partial agonist of the serotonin 5-HT1A receptor.

In CHO cells expressing human 5-HT1A receptors, perospirone shows a high affinity (Ki = 0.72 nM), and exhibits partial agonistic efficacy.

Tetrahydroberberine is an isoquinoline alkaloid isolated and purified from the barks of Phellodendron chinense Schneid. It has micromolar affinity for dopamine D(2) (pK (i) = 6.08) and 5-HT(1A) (pK (i) = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors(5-HT(1B), 5-HT(1D), 5-HT(3), and 5-HT(4); pK (i) < 5.00).

Ropinirole HCl selectively inhibit dopamine D2 receptor with Ki of 29 nM. It is used for the treatment of spontaneous parkinson's disease.

Rotundine is antagonist for domapmine D1 receptor(Ki = 124 nM) and has a lower binding activity of domapmine D2 receptor and domapmine D3 receptor. It can also inhibit 5-HT1A (Ki = 340 nM).

Olanzapine is a multiple-target antagonist for 5-HT2A receptors and D2 dopamine receptors, as well as muscarinic M3 receptor.

Domperidone is an antagonist of dopamine D2 receptor and the IC50 value for rat D2 receptor is 13.6 nM.

Phenothiazine, a dopamine2 (D2) receptor antagonist, could reduce the expression of dopamine in the brain.

Levosulpiride, an atypical antipsychotic, can selectively inhibit D2 receptor and it is the (S)-enantiomer of sulpiride.

Pridopidine exhibits high affinity towards sigma 1 receptor (S1R) (Ki = 70-80 nM) which can counteract the effects of excessive or insufficient dopaminergic transmission and it can used as a dopamine (DA) stabilizer.

Molindone HCl, the salt form of molindone which is a dopamine receptor antagonist, can be used in the treatment of schizophrenia and act as a therapeutic antipsychotic.

Sulpiride is a typical antipsychotic drug that binds to dopamine D2 receptor. Sulpiride is an effective treatment for schizophrenia and depressive disorder.

Prochlorperazine dimaleate is an antagonist of dopamine (D2) receptor with Ki value of 4.7 nM.

Metoclopramide is an antagonist of dopamine D2 and is commonly used as an antiemetic.

Trifluoperazine is a typical antipsychotic of the phenothiazine chemical class.

Loxapine succinate salt is an multiple-target antagonist of both D2/D4 dopamine receptor and 5-HT2A/2B, 5-H7 serotonin receptor, used as an antipsychotic agent.