Chlorprothixene is an antagonist of multiple receptors including 5-HT2 (Ki = 3.4 nM), D1 (Ki = 18 nM), D2 (Ki = 18 nM), D3 (Ki = 4.56 nM), H1 (Ki = 3.75 nM), muscarinic acetylcholine receptors, α1-Adrenergic.

SCH 23390 HCl is an antagonist of dopamine receptor D1 and D5 with Ki of 0.2 nM and 0.3 nM, respectively.

Ansofaxine HCl is a multiple-target reuptake inhibitor with IC50 values of 723nM, 491nM and 763nM for serotonin, dopamine and norepinephrine reuptake.

Rotundine is antagonist for domapmine D1 receptor(Ki = 124 nM) and has a lower binding activity of domapmine D2 receptor and domapmine D3 receptor. It can also inhibit 5-HT1A (Ki = 340 nM).

Loxapine succinate salt is an multiple-target antagonist of both D2/D4 dopamine receptor and 5-HT2A/2B, 5-H7 serotonin receptor, used as an antipsychotic agent.

Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; also inhibits STAT3 and STAT5.

Penfluridol, a T-type calcium channel blocker, is a highly potent, first generation diphenylbutylpiperidine antipsychotic.