ML216 is a potent inhibitor of the DNA unwinding activity of BLM helicase, showing similar IC50s of 3.0 and 0.97 μM for full length BLM and BLM636–1298 respectively.

Brr2 inhibitor C9 is an allosteric inhibitor targeting the spliceosomal RNA helicase Brr2, which implicated in autosomal-dominant retinitis pigmentosa, a group of progressive retinal degenerative disorders.

RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.

YK 4-279 is a potent inhibitor of RNA Helicase A (RHA) that binding to the oncogenic transciption factor EWS-FLI1.