Cytarabine is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells.

Daunorubicin HCl can inhibit both DNA synthesis (Ki = 0.02 μM) and RNA synthesis.

Acelarin is a ProTide transformation and enhancement of the widely-used nucleoside analogue, gemcitabine.

Cisplatin is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts. It is used, alone or in combination therapy, in the treatment of several types of cancer, including testicular, ovarian, cervical, bladder, and lung cancers. Cisplatin also inhibits the RecA recombinase of M. tuberculosis (IC50 = 2 µM), blocking protein splicing and cell growth.

Carboplatin is a chemotherapy drug by binding to DNA and interfering with the cell's repair mechanism.

Oxaliplatin inhibits DNA synthesis by conforming DNA adducts.

Bendamustine is a DNA cross-linking agent.

Daptomycin is a lipopeptide antimicrobial agent with activity against Gram-positive organisms, including multi-resistant strains.

Metronidazole is an inhibitor of OAT3 and can inhibit the transport activity of OAT3 with IC50 and Ki of 6.51 ± 0.99 μM, 6.48 μM, respectively. It is also an antibacterial agent for anaerobic bacteria and protozoa.

Trifluorothymidine is a derivative of thymidine that can inhibit thymidylate synthase and lead to DNA damage and apoptosis. It could be used to treat colorectal cancer.

Nedaplatin is a derivative of cisplatin and DNA damage agent.

Cidofovir is an anti-CMV drug which can suppress CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription.

Robinetin, a natural product isolated and purified from the leaves of Robinia pseudacacia, has antioxidant and antiradical activities, inhibits EYPC membrane lipid peroxidation and HbA glycosylation with high efficiency.

Fexinidazole is a 5-nitroimidazole drug for the treatment of human sleeping sickness (human African trypanosomiasis [HAT]), caused by infection with species of the protozoan parasite Trypanosoma brucei.

Oxolinic acid is a potent inhibitor of DNA gyrase and DNA synthesis, lead to DNA cleavage when extracted chromosomes are incubated with sodium dodecyl sulfate.

Blasticidin S inhibits protein synthesis by acting on the step of peptide transfer from peptidyl-sRNA to incoming aminoacyl-sRNA.