DHODH-IN-11, a leflunomide derivative, is a weak inhibitor of dihydroorotate dehydrogenase (DHODH) with pKa of 5.03.

G6PDi-1 is a reversible and noncompetitive G6PDH inhibitor with IC50 value of 0.07µM.

Pyrazinoic Acid inhibits Mycobacterial Coenzyme A biosynthesis by binding to aspartate decarboxylase PanD.

ASP 9521 is a potent and selective AKR1C3 inhibitor with IC50 of 11 nM for human AKR1C3.

GSK2837808A is a potent and selective LDHA and LDHB inhibitor with IC50 values of 2.6nM and 43nM for LDHA and LDHB, respectively. It reduces glucose uptake and enhances mitochondrial oxygen consumption in Snu398 hepatocellular carcinoma cells.

LDH-IN-1 is a novel pyrazole-based inhibitor of human lactate dehydrogenase (LDH) with IC50s of 32 and 27 nM for LDHA and LDHB, respectively.

TC HSD 21 is a potent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor with an IC50 of 14 nM. TC HSD 21 shows excellent selectivity over 17β-HSD isoenzymes and nuclear receptors[1].

3-Methylpyrazole is a nitrification inhibitor of nitrification in soil.

Carbenoxolone disodium is a glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication.

HQNO is a potent respiratory inhibitor produced by Pseudomonas aeruginosa. It is a competitive inhibitor of quinone and targets the Q-site of NDH-2.

Brequinar sodium is a potent inhibitor of the mitochondrial DHODH, a rate-limiting enzyme in the pyrimidine de novo nucleotide synthesis.

AG-636 is a potent, reversible, selective and orally active DHODH inhibitor with IC50 value of 17nM.

Teriflunomide, the active metabolite of an approved antirheumatic drug leflunomide, is an emerging oral therapy for multiple sclerosis (MS). It reversibly inhibits dihydroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines.

2-Bromoacetamide can inactivate alcohol dehydrogenase.

BVT 2733 is a small molecule, non-steroidal, isoform-selective inhibitor of 11beta-hydroxysteroid dehydrogenase type 1(11β-HSD1).

Galloflavin is an inhibitor of both LDH-A and -B with Ki values of 5.46 μM (LDH-A) and 15.06 μM (LDH-B), respectively. It inhibits both human LDH isoforms by preferentially binding the free enzyme, without competing with the substrate or cofactor.

Penthiopyrad is a carboxamide fungicide used to control a broad spectrum of diseases on large variety of corps and inhibits fungal respiration by binding to mitochondrial respiratory complex II.

FX11 is a selective, reversible, and NADH competitive inhibitor of LDHA with Ki value of 8µM.