Danirixin is a small molecule, non-peptide, high affinity (IC50 for CXCL8 binding = 12.5 nM), selective, and reversible CXCR2 antagonist.

SRT3109 is a CXCR2 ligand for use in the treatment of chemokine mediated diseases and conditions.

AMG-487 is a small molecule antagonist of the chemokine receptor CXCR3 and inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3.

TAK-779 is a highly potent and selective nonpeptide CCR5 antagonist with a IC50 value of 1.4 nM in the binding assay. TAK-779 also inhibits the replication of macrophage (M)-tropic HIV-1 (Ba-L strain) in both MAGI-CCR5 cells and PBMCs with EC50 values of 1.2 and 3.7 nM, respectively.

AMD-070 is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.

ML 145 is a selective antagonist of the GPR35 orphan receptor with IC50 of 20.1 nM.

IT1t 2HCl is a potent CXCR4 antagonist with IC50 of 1.1 nM.

MSX-130 is CXCR4 Antagonist.

AMD 3465 is a potent, selective CXCR4 antagonist and exhibits 8-fold higher affinity than AMD 3100 and inhibits SDF-1α-ligand binding (Ki = 41.7 nM).

BKT140 is a CXCR4 antagonist with an IC50 value of ~1 nM.

LIT-927 is a neutraligand of CXCL12 (Ki= 267 nM) with anti-inflammatory effect and it has a high binding selectivity for CXCL12 over other chemokines

JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM.

AMD-070 is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.