Entacapone sodium is a specific, potent, peripherally acting catechol-O-methyltransferase (COMT) inhibitor with IC50 of 151 nM for PD treatment.

Opicapone is a long-acting, peripherally selective inhibitor of catechol-O-methyltransferase.

Entacapone is a specific, potent and peripherally acting catechol-O-methyltransferase (COMT) inhibitor with IC50 of 151 nM for PD treatment.

Flopropione is both a 5-HT1A receptor antagonist and a COMT inhibitor as a spasmolytic or antispasmodic agent.

Tolcapone is a potent, selective and orally active catechol-O-methyltransferase (COMT) inhibitor with Ki of 30 nM.

HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7 activity with IC50 of 424 nM.