PF-06928215 is a cyclic GMP-AMP synthase (cGAS) inhibitor with IC50 of 4.9 μM in the presence of 1 mM ATP, 0.3 mM GTP, 100 nM 45-bp interferon-stimulatory dsDNA (ISD).

G150 is a potent and highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor for repression of dsDNA-triggered interferon expression, with an IC50 of 10.2 nM[1].

IRAK4-IN-4 is an interleukin-1 receptor–associated kinase 4 (IRAK4) inhibitor with IC50 of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with IC50 of 2.1 nM.

RU-521 is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor with Kd of 36.2 nM.