Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC50s of 17 and 15 μM for Z- and E-Guggulsterone, respectively.

Ac-DEVD-CHO is a potent and specific Caspase-3 inhibitor with Ki of 230 pM.

Alisol B is a natural product isolated and purified from the tubers of Alisma plantago-aquatica Linn. for bone disorders by targeting the differentiation of osteoclasts as well as their functions.

Chonglou saponin VII, a natural product isolated and purified from the roots of Paris polyphylla, shows inhibitory effects on cell proliferation.

Emricasan, also called IDN-6556 or PF-03491390, is an inhibitor of activated caspases, and it has sub- to nanomolar activity in vitro.

CASP3 Activator 1541 is an activator of procaspase-3.

Agnuside, a natural product isolated and purified from the herbs of Vitex negundo L., has anti-arthritic activity. Agnuside shows inhibition of vascular permeability and leukocyte migration in vivo.

Phytohemagglutinin (PHA-M), a lectin extract from the red kidney bean and a standard T cell mitogen, as an inhibitor of both T- and B-cell tumors. Phytohemagglutinin can inhibit incorporation of 3H-thymidine and mediate apoptosis of B- and T-cell tumor lines. Anti-tumor activity .

AS101 is a potent Caspase-1 inhibitor which can inhibit IL-10 synthesis and potentiates IL-1α, IL-2 and TNF-α release through Caspase, performing as an immunomodulator.

Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate) prevents apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid sodium hydrate is investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis.

Z-DEVD-FMK (1–200 μM) inhibits D4-GDI cleavage and apoptosis in a concentration-dependent manner.