MYCi975 improved analog of MYCi361 which is a MYC inhibitor. It showed better tolerability compared with MYCi361.

KJ Pyr 9 is a small-molecule inhibitor of MYC. The Kd of KJ Pyr 9 for MYC in vitro is 6.5±1.0 nM, as determined by backscattering interferometry.

MYCi361 is a MYC inhibitor with Kd value of 3.2μM. It engages MYC inside cells, disrupts MYC/MAX dimers, and impairs MYC-driven gene expression. MYCi361 suppressed in vivo tumor growth in mice, increased tumor immune cell infiltration, upregulated PD-L1 on tumors, and sensitized tumors to anti-PD1 immunotherapy.

Mycro3 is a small-molecule inhibitor of Myc-Max dimerization. The average residual tumor of Pdx1-cre/KRAS* mice after Mycro3 treatment (100mg/kg, orally, daily for 2 months) is approximately 30%.

MYCMI-6 (NSC354961) is a potent and selective endogenous MYC:MAX protein interactions inhibitor. MYCMI-6 blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with a Kd of 1.6 μM. MYCMI-6 inhibits tumor cell growth in a MYC-dependent manner (IC50<0.5 μM). MYCMI-6 is not cytotoxic to normal human cells. MYCMI-6 induces apoptosis .

Agrimol B is a natural product isolated and purified from the herbs of Agrimonia pilosa Ledeb.

10074-G5 is a c-Myc Max interaction inhibitor.