Brusatol is a plant-derived natural quassinoid that exhibits broad cytotoxicity in cancer cultures (IC50 < 1 μM against 457 cancer cell lines) by inhibiting de novo synthesis of cellular proteins (Effective conc. < 50 nM in A549 cells), including NRF2.

Bruceine A is a natural quassinoid compound extracted from the dried fruits of Brucea javanica (L.) and is a potential candidate for the treatment of canine babesiosis.

Bruceine D, a natural product isolated and purified from the barks of Ailanthus altissima, may have the potential to be used as a natural viricide, or a lead compound for viricides, inhibits the growth of three pancreatic cancer cell lines, i.e., PANC-1, SW1990 and CAPAN-1, and induces cytotoxicity in Capan-2 cells via the induction of cellular apoptosis involving the mitochondrial pathway.

Bruceantin is first isolated from Brucea antidysenterica, a tree used in Ethiopia for the treatment of cancer, and activity was observed against B16 melanoma, colon 38, and L1210 and P388 leukemia in mice.