Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC50s of 17 and 15 μM for Z- and E-Guggulsterone, respectively.

Brazilin, a red dye precursor obtained from the heartwood of several species of tropical hardwoods, inhibits the cells proliferation, promotes apoptosis, and induces autophagy through the AMPK/mTOR pathway. Brazilin shows chondroprotective and anti-inflammatory activities.

AGN 196996 is a potent and selective RARα antagonist with Ki value of 2 nM showing little binding affinity for RARβ (Ki=1087 nM) and RARγ (Ki=8523 nM).

Veliparib 2HCl is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM, respectively.

BMS-582949 HCl is a highly selective p38α MAPK inhibitor, inhibits p38α with IC50 of 13 nM.

PF-4708671 is an inhibitor of S6K1 (p70 ribosomal S6 kinase 1) with Ki and IC50 of 20 nM and 160 nM, respectively.

SMER18 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer.

LY2183240 is a highly potent blocker of anandamide uptake (IC50 = 270 pM).

MHY1485 is a mTOR activator and inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes leading to the accumulation of LC3II protein and enlarged autophagosomes.

KJ Pyr 9 is a small-molecule inhibitor of MYC. The Kd of KJ Pyr 9 for MYC in vitro is 6.5±1.0 nM, as determined by backscattering interferometry.

Pantoprazole is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.

PF-06447475 is a brain-penetrant, potent and selective LRRK2 inhibitor with IC50 values of 3 nM, possessing neuroprotective activity.

AT101 acetic acid, the R-(-) enantiomer of gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM.