BEZ235 is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell.

VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM.

Torin 2 is a potent and selective mTOR inhibitor with IC50 of 0.25 nM, showing 800-fold greater selectivity for mTOR than PI3K and improved pharmacokinetic properties and inhibition of ATM/ATR/DNA-PK with EC50 of 28 nM/35 nM/118 nM, respectively.

VE-822 is an ATR inhibitor with IC50 of 19 nM in HT29 cells.

ETP-46464 is a cell-permeable quinoline-containing heterotricyclic compound that acts as a potent inhibitor against mTOR, ATR, DNA-PK, PI 3-Kα, and ATM (IC50= 0.6, 14, 36, 170, and 545 nM, respectively).

CGK 733 is an inhibitor of ATM and ATR with IC50 of ~200 nM, also induces cell death in prematurely senescent breast cancer cells.

AZ 20 is a potent and selective inhibitor of ATR with an IC50 of 5 nM exhibiting 8-fold selectivity over mTOR (IC50=38 nM).

AZD6738 is a highly selective and potent inhibitor of ATR kinase activity with IC50 value of 1nM in isolated enzyme assay and showed inhibitory effect on ATR kinase-dependent cellular Chk1 phosphorylation with IC50 value of 74nM.

Schisandrin B is a naturally occuring anti-inflammatory and antioxidant agent which can inhibit ROS production in microglia.