VE-822 is an ATR inhibitor with IC50 of 19 nM in HT29 cells.

AZD0156 is a potent and selective inhibitors of ATM kinase, with potential chemo-/radio-sensitizing and antineoplastic activities.

BAY-1895344 is a potent and selective ATR inhibitor with IC50 of 7 nM.

KU-60019 is an improved analogue of KU-55933, with IC50 of 6.3 nM for ATM.

KU-55933 is a potent ATM inhibitor with an IC50 and Ki of 13 and 2.2 nM, respectively and highly selective for ATM as compared to DNA-PK, PI3K/PI4K, ATR and mTOR.

AZ32 is an ATM inhibitor with IC50 <6.2 nM in enzyme assays and 310 nM in cellular assays.

AZ 20 is a potent and selective inhibitor of ATR with an IC50 of 5 nM exhibiting 8-fold selectivity over mTOR (IC50=38 nM).

CGK 733 is an inhibitor of ATM and ATR with IC50 of ~200 nM, also induces cell death in prematurely senescent breast cancer cells.

AZD1390 is an ATM inhibitor with IC50 of 0.78 nM in cells.

Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor, and inhibits Mre11-associated exonuclease activity.

AZD6738 is a highly selective and potent inhibitor of ATR kinase activity with IC50 value of 1nM in isolated enzyme assay and showed inhibitory effect on ATR kinase-dependent cellular Chk1 phosphorylation with IC50 value of 74nM.

VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM.

ATR inhibitor 2 is an ATP-competitive, orally active, and selective ATR inhibitor, with a Ki of <150 pM. ATR inhibitor 2 potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation with an IC50 of 8 nM. Antitumor activity[1][2].

CP-466722, a potent and reversible ATM inhibitor, does not affect ATR and inhibits PI3K or PIKK family members in cells.

BEZ235 is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell.

Chloroquine Diphosphate is an inhibitor of autophagy/lysosome and Toll-like receptor (TLR) signalling, also acting as an ATM acitivator, it's an antimalarial drug.

ETP-46464 is a cell-permeable quinoline-containing heterotricyclic compound that acts as a potent inhibitor against mTOR, ATR, DNA-PK, PI 3-Kα, and ATM (IC50= 0.6, 14, 36, 170, and 545 nM, respectively).