Monobutyl phtalate is a metabolite of di(n-butyl)phthalate. It affects the expressions of EMT-related proteins and enhances the migration and invasion of MLTC-1 cells.

Triptophenolide is a colorless crystalline plate isolated from ethyl acetate extracts of Tripterygium wilfordii.

Hydroxyflutamide is a derivative of the synthetic steroid ethisterone, that suppresses the production of gonadotrophins, and has some weak androgenic effects.

3,3'-Diindolylmethane is an AR structurally similar androgen receptor antagonist.

ARCC-4 is a PROTAC, acting as an androgen receptor degrader. ARCC-4 is a low-nanomolar androgen receptor degrader able to degrade about 95% of cellular androgen receptors. ARCC-4 inhibits prostate tumor cell proliferation, degrades clinically relevant androgen receptor point mutants and unlike enzalutamide, retains antiproliferative effect in a high androgen environment. Thus, ARCC-4 exemplifies how protein degradation can address the drug resistance hurdles of enzalutamide.

N-Desmethyl enzalutamide is a major metabolite of Enzalutamide, Enzalutamide (MDV3100) is an androgen-receptor (AR) antagonist with IC50 of 36 nM.

ORM-15341 is a potent and full antagonist for human AR (hAR) with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells stably expressing full-length hAR and an androgen-responsive luciferase reporter gene construct.

ARN-509 can compeitively and selectively inhibit androgen receptor with IC50 value of 16 nM.