Sciadopitysin, a natural product isolated and purified from the leaves of Ginkgo biloba L., can inhibit the Aβ aggregation and reduce Aβ-induced toxicity in the primary cortical neurons.

Tabersonine, a natural product isolated and purified from the root bark of Voacanga africana Stapf, is a precursor for vincristine used in cancer chemotherapy, the biocompatibility and small size essential for permeating the blood-brain barrier make it a potential therapeutic drug candidate for treating AD.

Schisandrone is extracted from the fruits of schisandra sphenanthera.

Direct Red 80 has been used as an ingredient in the preparation of saturated picric acid for immunohistochemical detection and quantitation of collagen in liver tissues.

Amyloid P-IN-1 is a potential compound for treating amyloidosis, Alzheimer's disease, type 2 diabetes mellitus and osteoarthritis.

DC-Chol is a cationic cholesterol derivative. DC-Chol, as a component of lipoplexes with DOPE, has been used for transfection of mRNA into A549 cells without affecting cell viability. Incubation of DC-chol/DOPE liposomes or lipoplexes with human whole blood has no effect on neutrophil elastase or β-thromboglobulin levels or the number of platelets and red and white blood cells, indicating hemocompatibility. DC-Chol has also been widely used in the synthesis of liposomes for the delivery of siRNA, DNA, and chemotherapeutic agents into cells and mice.

EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.

Amyloid-beta (Abeta) Protein Aggregation Inhibitors, Antiamyloidogenic Agents

PE859 is a Curcumin-derived inhibitor of Amyloid-β and Tau aggregation and can ameliorate cognitive dysfunction in senescence-accelerated mouse Prone 8.

ARN2966 is a potent post-transcriptional modulator of APP expression and reduces expression of APP with resultant lower production of Aβ.